Effect of Kidney Biochemical Enzymes in Ethylene Glycol Induced Urolithiatic Rats Treated with Scopariadulcis (leaf)

Scopariadulcis has long held a place in herbal medicine in every tropical country where it grows, and its use by indigenous peoples is well documented. The decoction of the entire plant is recommended for upper respiratory problems, biliary colic or congestion, menstrual disorders, and fever; the leaf juice is still employed externally for wounds and hemorrhoids. In Brazilian herbal medicine the plant is used to reduce fever, lower blood sugar and blood pressure, and as an expectorant for coughs and lung congestion. A tea is prepared from the leaves or aerial parts of the plant for fevers and urinary tract diseases, upper respiratory disorders, bronchitis, coughs, menstrual disorders, and hypertension.The Scopariadulcishave active biological properties, including its anti-cancerous properties, are attributed to the phytochemicals. Many studies report that this phytochemical has powerful anticancerous, antitumorous, antileukemic, and antiviral (including HIV) properties. This potent phytochemical has displayed selective cytotoxic activity against malignant brain tumors, bone cancer, and melanomas (without harming healthy cells).The present study focussing on the effect of the ethanolic leaf extract of Scopariadulcis on the urolithiatic and control kidney marker enzymes. The urolithiatic condition on the experimental animal is induced by 30 days oral administration of 0.75% of Ethylene glycol. Then the ethanolic leaf extract of the plant were administered in 250 mg/kg body weight of rats orally for 30 days to the toxic group as a treatment. The variations in the kidney biochemical parameters in this urolithiatic study shows decrease level of the marker enzymes (Acid phosphatase, Alakalinephosphatase, Aspartatetrasaminase& Alanine trasaminase). On treatment with the plant extract , the normal levels are approximately regained. This study concluded that the ethanolic leaf extract of Scopariadulcis can be able to recover the kidney marker enzymes level of urolithiatic toxic rats. This will give a hope for the formulation of Antiurolithiatic drug using Scopariadulcis by analyzing other parameters simultaneously.